在韩春雨和罗湘南提到的这篇《自然》杂志报道中,David Cyranoski提到的是,有一名不愿透露姓名的中国研究人员在几个细胞系中检测了NgAgo系统,结果显示NgAgo能在预期的位点诱导遗传突变。这位匿名的研究人员表示NgAgo系统的效率比CRISPR-Cas9低,但总的来说有效。David Cyranoski还提到,另两位匿名的中国学者表示有初步试压结果显示NgAgo有效,但是仍需要进一步测序确认。
另据《科技日报》报道,9月6日,施普林格·自然集团大中华区总裁刘珺回应科技日报记者:“对于韩春雨论文的调查,我们目前还维持之前的官方回应,尚未有新的结果公布。”
早在8月2日,刊登论文的英国《自然》杂志子刊《自然·生物技术》向媒体发表官方声明表示,《自然·生物技术》将按照既定流程来调查此事。
施普林格·自然集团董事长斯蒂芬·冯·霍尔茨布林克告诉科技日报记者:“作为科研论文的出版机构,我们在工作中也发现了可重复性研究的问题。它并不是一个新问题,但是随着新的科研成果的增多,实验的可重复性问题被暴露了出来。未来我们会要求投稿人在投稿中增加更多的实验细节,并且在明年我们也会要求投稿人将他们的数据表格化呈现给编辑。”
斯蒂芬介绍,鼓励科研人员参与可重复性实验是他们下一步工作目标之一。自然集团会考虑引用新的形式来帮助做可重复性实验的科研人员发表论文,同时帮助人们对新的科研成果建立起信心。“科研管理机构更关注有新突破的实验结果而忽略了重复性实验,现在他们也开始关注这个问题。”斯蒂芬说。
要进行可重复性实验,就要做好实验数据管理。对此,斯蒂芬提到了FigShare,一种分享开放科研数据的新方式。它是自然集团的姊妹公司数码科学(Digital Science)旗下的产品,可以让实验人员管理实验数据并快速分享。斯蒂芬表示,未来会鼓励科研人员使用这种数据管理软件,以帮助其他科研人员进行可重复性实验。
自然杂志记者David Cyranoski邮件原文如下:
I have not read the original article in Chinese so I cannot comment on that quotation from Dr. Han. There might have been some kind of miscommunication.
What I can say is that my news article should not be taken as evidence that Dr Han' experiments are reproducible. I did not carry out any independent replication experiments, and thus cannot add any first-hand knowledge regarding the findings. My article does reflect that there are differences of opinion about the reproducibility of Dr Han's experiments, and as far as I know, that controversy has not yet been resolved.
My work as part of the Nature news team and the Nature Biotechnology editorial team are distinct, so I cannot comment on that journals investigation into the matter.
By the way, have you tried to confirm with Dr Han that he actually said that?
《自然-生物技术》发言人邮件原文如下:
The article published in Nature on August 8th is a piece of journalistic reporting by the Nature’s news team and should not be considered to be validation of the integrity of the research. Nature’s news team is editorially independent from the research editorial teams of Nature Biotechnology, the journal Nature and the other Nature-branded journals and any views or conclusions reported in news articles should not be considered to be the views of the research editorial teams.
Nature Biotechnology is following established process to investigate the issues.
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